Rhima Coleman PhD

Dr. Rhima Coleman from the University of Michigan. She is an Assistant Professor in Biomedical Engineering. On Both Sides of the Cell Membrane: The Effect of Microenvironmental Parameters and Synthetic Gene Circuits on Mesenchymal Stem Cell Chondrogenesis and Maturation Abstract: While tissue engineering with adult mesenchymal stem cells (MSCs) offer exciting alternative therapies for repairing traumatic cartilage injury, many challenges remain with respect to engineering a functional replacement, due, in part, to our incomplete understanding of microenvironmental influences on stem cell fate and chondrocyte maturation. I will present a pre-chondrogenic stem cell niche developed in my lab in which we systematically investigate the combinatorial effects of multiple exogenous cues on early chondrogenesis and long-term phenotype in a high-throughput format.