R. Balfour SartorMD
Dr. R. Balfour Sartor is a gastroenterologist and mucosal immunologist working at the Center for Gastrointestinal Biology and Disease, Department of Medicine, Microbiology and Immunology, at the University of North Carolina (USA). He is co-director of the Center for Gastrointestinal Biology and Disease.
Sartor recently wrote an article called "The Intestinal Microbiota in Inflammatory Bowel Diseases", published in Nutrition, Gut Microbiota and Immunity: Therapeutic Targets for IBD, from the 79th Nestlé Nutrition Institute Workshop. The article highlights the abnormal fecal bacterial profiles observed in pouchitis, Crohn's disease and ulcerative colitis. Sartor argues bacterial function is more important than composition; key pathways are shared, so the presence of certain bacterial groups can functionally compensate for the absence of others. In addition, he notes, different bacterial groups can synergistically interact.
Sartor says the goal of therapy for inflammatory bowel diseases should be to restore a more homeostatic profile of bacteria, fungi, viruses. He goes on to explain a current theory of Crohn's disease pathogenesis involving genes, environment, microbiota, and immune factors.