Dr. Donofrio graduated cum laude from the University of Notre Dame in 1972 and earned his medical degree from The Ohio State University in 1975. He completed a medicine residency at Good Samaritan Hospital in Cincinnati, Ohio, and a neurology residency and fellowship at the University of Michigan. After serving on the faculty of the University of Michigan for 5 years, he moved to Wake Forest University in 1986, where he was a faculty member for 20 years. In 2006, he accepted the position of Chief of the Neuromuscular Section in the Department of Neurology at Vanderbilt University. In addition, he is the Head of the Muscular Dystrophy Association Clinic, the ALS Clinic, and is the Director of the EMG Lab.
Dr. Donofrio is presently on the Board of Directors of the American Academy of Neuromuscular and Electrodiagnostic Medicine (AANEM) and serves on the Medical Economics and Management Committee of the American Academy of Neurology. In 1994, he was elected to the prestigious American Neurological Association. In the past, he served on the Board of Directors of the North Carolina Chapter of the Amyotrophic Lateral Sclerosis Association. He was President of the North Carolina Neurological Society from 2001 to 2005 and is the President-Elect of the AANEM. Dr. Donofrio is board certified in internal medicine, neurology, and electromyography.