Patrick Revy PhD

Dr Patrick Revy, PhD, works at the Imagine Institute (Necker hospital) in Paris (France). He co-heads the laboratory "Genome dynamics in the immune system" with Jean-Pierre de Villartay. The primary goal of the Lab is to identify the molecular mechanisms of genetic disorder of the immune system accompanied by DNA repair defect and/or telomere dysfunction in humans. This serves as the basis for both basic studies on the function and the regulation of the immune system and for medical application in the diagnosis and treatment of diseases. Patrick Revy has contributed to the description of several molecular defects associating DNA repair/modification defects or telomere dysfunction with bone marrow failure syndromes and immunodeficiencies. His team is particularly interested in the study of telomere biology disorders leading to inherited bone marrow failure and Hoyeraal-Hreidarsson syndrome (a severe variant of Dyskeratosis Congenita).