Paloma H. Giangrande PhD

Dr. Giangrande is the Vice President of Biology at Wave Life Sciences in Cambridge, MA. She obtained her Bachelor of Science degree in Biochemistry at Wheaton College, Norton, MA in 1994 and her Ph.D. in Pharmacology and Cancer Biology at Duke University, Durham, NC in 1999. Her career has been dedicated to the investigation and development of RNA-based therapeutic approaches (including RNA aptamers, siRNAs, mRNA, and RNA editing) for cancer, cardiovascular disease, rare diseases, and critical illness.

As a consequence, Dr. Giangrande developed a deep understanding of these technologies, diseases, and associated disease mechanisms. She is an internationally recognized expert in oligonucleotide therapeutics and delivery. Towards this end, she was the first to demonstrate that RNA ligands (aptamers) can be used to deliver therapeutic siRNAs to target cells. Her 70+ publications and 9+ patents are a testament to this body of work and her commitment to the development of novel RNA-based therapies for many diseases.