Paloma H. GiangrandePhD
Paloma H. Giangrande, PhD, is an Associate Professor in the Department of Internal Medicine at The University of Iowa and an internationally recognized expert in oligonucleotide therapeutics and delivery. After earning her PhD degree in Pharmacology and Cancer Biology at Duke University in 1999, Dr. Giangrande trained as a postdoctoral fellow in the Department of Molecular Genetics at Duke where she focused on elucidating the roles of the E2F transcription factors in cell cycle control. She was then promoted to Research Assistant Professor in the Department of Surgery at Duke where she pioneered cell- and molecular- targeted RNA technologies for treating cancer and cardiovascular disease.
Dr. Giangrande joined the Department of Internal Medicine at The University of Iowa in 2007. In May 2013, she was awarded the Outstanding New Investigator Award from the American Society of Gene & Cell Therapy (ASGCT) for distinguished research in RNA-based cell-targeted technologies. (Watch her online winner’s video here.) The central goal of Dr. Giangrande’s research program is on elucidating mechanisms of deregulated cell growth and survival and applying this knowledge to develop “smart” therapies with favorable efficacy and safety profiles. She was the first to demonstrate that RNA aptamers can be used to deliver therapeutic RNAi modulators (siRNAs and miRNAs) to target cells.
Her recent work explores aptamer-based selection methodologies for establishing a framework for developing cell-targeted approaches for the diagnosis and therapy of many diseases, including cancer, cardiovascular disease and diabetes.