Nancy Maizels PhD

Dr. Maizels was an undergraduate at the University of California at Berkeley. She received her Ph.D. from Harvard University, and she continued at Harvard as a Junior Fellow of the Society of Fellows. She was a Professor in the Departments of Molecular Biophysics & Biochemistry and Genetics at Yale University School of Medicine before coming to the University of Washington in Fall, 2000.

We are working to define the enzymes that introduce and repair DNA breaks during immunoglobulin class switch recombination and somatic hypermutation in activated B cells. These processes depend largely on factors involved in maintenance of genomic stability. Diminished function of these factors over an individual's lifetime almost certainly contributes to reduction in the efficiency of switch recombination and somatic hypermutation with age.

Dr. Maizels came from Yale University School of Medicine in 2000 and is Professor, Departments of Immunology and Biochemistry. At Yale she was Director, Cellular and Molecular Biology Training Program, 1995-2000. She served as a member on the NIH Mammalian Genetics Study Section, 1996-2000 and on the NCI Special Review Committee, 2001, and as a reviewer for the NSF Biochemistry of Gene Expression Panel, 2001. She also participates on the NIH Biomedical Research and Research Training Review Committee, 2000-2004.