Min-xin Guan PhD

Dr. Min-Xin Guan graduated with BS in biology from Hangzhou University (previous and current Zhejiang University) in 1983. He did his postgraduate study at the Australian National University (Ph.D. 1993; Advisor: Professor G. Desmond Clark-Walker). Dr. Guan conducted postdoctoral research in the laboratory of Professor Giuseppe Attardi at the California Institute of Technology (1993-1999). In 1999, he started his independent research as an assistant professor at Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, eventually becoming a full professor in the Division of Human Genetics, at Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine in 2011. Since 2011, he has been joining the faculty at Zhejiang University as the founding Director of the Institute of Genetics, Dean of the College of Life Sciences (2011-2013), and Associate Dean of the Faculty of Medicine and Pharmaceutical Sciences (2015-2022). Dr. Guan's research interests focus on human mitochondrial genetics and biomedicine. Guan’s pioneering work with mitochondrial diseases included the discoveries of the mitochondrial cause of maternally inherited nonsyndromic and aminoglycoside-induced hearing loss. Dr. Guan's recent pioneering work was the finding of how the interactions between mtDNA mutations and nuclear modifiers manifested deafness and Leber's hereditary optic neuropathy. Currently, Dr. Guan's lab is focusing on investigating the mechanisms underlying the aberrant mitochondrial tRNA metabolisms including the synthesis, processing, maturation, CCA addition, posttranscriptional nucleotide modification, and aminoacylation of tRNA, and their impact on human diseases including deafness, optic neuropathy, and hypertension. Dr. Guan has published 184 manuscripts on mitochondrial diseases in high-impact journals. Dr. Guan served as the 4th president of the Asian Society of Mitochondrial Research and Medicine (2011-2014).