Dr. Simons is a graduate of Massachusetts Institute of Technology and Yale University School of Medicine. He completed his clinical training in internal medicine at the New England Medical Center in Boston and cardiology training at the Beth Israel Hospital in Boston. He completed a postdoctoral fellowships in molecular cardiology at National Heart Lung and Blood Institute in Bethesda and in vascular biology at MIT.
In 1993 he joined faculty at Harvard Medical School as an Assistant Professor of Medicine and rose through the ranks to become an Associate Professor of Medicine, Director of the Morse Coronary Care Unit and Director of Angiogenesis Research Center. In 2001 he was recruited to Dartmouth as AG Huber Professor of Medicine and Chief of Cardiology, subsequently becoming Director of Dartmouth Cardiovascular Center.