Michael B. Brenner MD

Michael B Brenner MD is Theodore Bevier Bayles, Professor of Medicine, at Harvard Medical School, and Chief of the Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, USA. Dr. Brenner’s research involves basic and translational studies in T cell biology, antigen presentation, microbial, and autoimmunity. His laboratory identified and characterized gd T cells discovered the integrin molecule aEb7 (CD103) and its role in leukocyte homing and revealed a role for the CD1 antigen presentation system inactivation of T cells and NKT cells. More recently, his laboratory defined specific fibroblast subpopulations that are pathologically expanded in disease and defined a new T helper cell population, T peripheral helper (Tph) cells that implicated in antibody production in autoantibody-mediated diseases.

Dr. Brenner leads the Human Immunology Center at Brigham and Women’s Hospital that designs and implements high dimensional immunophenotyping, single-cell transcriptional analyses, and functional studies to deconstruct human autoimmune disorders, stratify patient populations, and identify candidate therapeutic target cells and pathways. He is a member of the National Academy of Sciences, USA, and has received the Lee C. Howley Prize for Research in Arthritis, USA, and the Carol-Nachman Prize in Rheumatology.