Michael A. Mancini

Dr. Michael Mancini is a tenured Associate Professor in the Department of Molecular & Cellular Biology, Baylor College of Medicine (BCM), and director of the Integrated Microscopy Shared Resource of the Dan L. Duncan Cancer Center at BCM. Dr. Mancini is the co-founder and co-director of the John S. Dunn Gulf Coast Consortium for Chemical Genomics. He is a member of the BCM Graduate School for Biomedical Sciences and active member of graduate programs in Molecular and Cellular Biology, and Structural and Computational Biology & Molecular Biophysics; he has trained ~30 undergraduate, graduate and postdoctoral members in his laboratory. Dr. Mancinci has been a pioneer in the development and application of high throughput microscopy (HTM) to quantitative analysis of cell function and to drug discovery research. These studies have led to the development of a novel, fully automated “ultra”-HCA approach to that can be applied to small molecule and RNAi screening applications. Dr. Mancini’s laboratory uses high resolution light microscopy, time lapse studies, and biophysical measurements of nuclear protein mobility to develop single cell assays to study the activity of steriod receptors and receptor co-regulators in breast and prostate cancer cells.