Michael A. Brehm PhD
Dr. Brehm has over 16 years of experience in biomedical research with extensive knowledge of immunological responses to infectious agents and to transplantation with non-self tissues. He received his Ph.D. in 1999 from the Department of Microbiology and Immunology at the Pennsylvania State University College of Medicine. During Dr. Brehm’s post-doctoral training at the University of Massachusetts Medical School, he investigated how sequential viral infections impact the ability of a host to generated protective immunity and how viral infections influence transplantation tolerance induced by costimulation blockade. In 2008, he joined the Diabetes Division at the University of Massachusetts Medical School to develop cutting edge mouse models that have been implanted with human cells and tissues to study human biology.
Dr. Brehm is currently an Assistant Professor in the Program in Molecular Medicine at the University of Massachusetts Medical School and a member of the UMass Diabetes Center of Excellence. Dr. Brehm’s research program is focused on understanding how human effector T cells are regulated in the context of infectious disease, alloimmunity, and autoimmunity. His laboratory is developing “humanized” mice to more effectively study human T cell biology. Dr. Brehm has published over 80 manuscripts and reviews and is supported by funding from the JDRF, NIH and the Helmsley Charitable Trust.