Markus got fascinated by the process of protein degradation early on during his Master’s thesis at Free University in Berlin, where he worked on proteasomal functions and ubiquitin-binding proteins. He further gained broad knowledge in respiratory diseases, inflammation and oncology while pursuing a Ph.D. in molecular biology and medicine of the lung in Germany and at Albert-Einstein College of Medicine in New York. He moved on to a postdoctoral fellowship at Northwestern University in Chicago, where in collaboration with Noble Laureate Aaron Ciechanover, he discovered a hypoxia-regulated ubiquitin-ligase. Prior joining GSK, he specialized in ubiquitin-ligase recruitment in ER-associated protein degradation at the Ludwig Institute for Cancer Research in Oxford. Currently, he is Scientific Leader within the Protein Degradation DPU, leading the technology branch.
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