Marius Sudol PhD

Marius Sudol was an Associate Professor in the Physiology Department at the National University of Singapore with joint appointments at the Mechanobiology Institute and the IMCB A*STAR (Agency for Science, Technology and Research) in the Republic of Singapore from 2014 to 2019. He also continued and still continues his association with the Department of Medicine at the Mount Sinai School of Medicine in New York City as an Adjunct Faculty. At the Icahn School of Medicine at Mount Sinai, Marius collaborates with Dr. Kirk Campbell on the role of YAP protooncogene, Dendrin and KIBRA proteins in kidney podocytes.

Marius Sudol was instrumental in the delineation and characterization of one of the smallest protein-protein interaction modules, the WW domain. His work identified cognate ligands of WW domains and implicated the WW domain in signaling pathways underlying several human diseases including Liddle syndrome of hypertension, Golabi-Ito-Hall syndrome of mental retardation and cancer. He earned a Ph.D. at The Rockefeller University in New York in 1983 and stayed at his Alma Mater as a postdoctoral fellow and faculty member until his move to Mount Sinai in 1995.

Marius has published more than 170 research articles and his current H-index on Google Scholar is 70. He also participated in the generation of the first protein interaction map for a human modular protein domain. His recent work was focused on signaling mechanisms that use WW domain complexes and underlie human diseases. In particular, his laboratory studied the Hippo-YAP/TAZ tumor suppressor pathway that is regulated by a network of multiple WW domain complexes and by mechanical signals. He also worked on the molecular mechanism of the Golabi-Ito-Hall (GIH) syndrome that is caused by a single point mutation within a WW domain. GIH syndrome phenocopies a severe form of autism. The mouse model of the GIH syndrome was generated by the Sudol laboratory in Singapore and now it is being characterized by the collaborative team of Professor Hitoshi Okazawa in Tokyo, Japan.