Mario L. Suva MD, PhD

Dr. Mario L. Suva is an Associate Professor of Pathology at Massachusetts General Hospital, a Principal Investigator, and the co-leader of the computational Support Group at Massachusetts General Hospital Cancer Center.

Dr. Mario Suva’s research has provided unprecedented insights into pediatric and adult brain tumors with single-cell genomic technologies. He leverages a systems biology approach to characterize and target the cellular states that drive gliomas. He pioneered and co-directed the first studies using single-cell RNA sequencing to comprehensively characterize the environments of pediatric and adult gliomas. His efforts have offered new insights into cancer stem cell programs, cancer cells lineages of differentiation, and the interplay between neural development and genetics in adult and pediatric brain tumors.

Suva earned his M.D. and Ph.D. from the University of Lausanne, Switzerland. His doctoral research identified cancer stem cells in Ewing sarcoma and highlighted mechanisms underlying their emergence. He conducted postdoctoral research at MGH and the Broad Institute with Brad Bernstein and David Louis, applying chromatin analysis and functional approaches to identify master regulators of glioma stem cell programs.