Marina Antoch MS, PhD

Dr. Antoch is currently Professor at Roswell Park Cancer Institute. She has received MS, PhD degrees from Moscow State University, Moscow, Russia. Her research interests are Circadian regulation of stress response pathways, Circadian clock and inflammation, Genetic models of aging.

Her Publications are as follows:
Gorbacheva VY, Kondratov RV, Zhang R, Cherukuri S, Gudkov AV, Takahashi JS, Antoch MP. Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proc Natl Acad Sci USA 102 (9):3407-3412, 2005. PMCID: PMC546637.
Kondratov RV, Kondratova AA, Gorbacheva VY, Vykhovanets OV, Antoch MP. Early aging and age-related pathologies in mice deficient in BMAL1, the core component of the circadian clock. Genes Dev 20(14):1868-1873, 2006. PMCID: PMC1522083.
Antoch MP, Chernov MV. Pharmacological modulators of the circadian clock as potential therapeutic drugs. Mut Res. 2009; 17-23.
Hu Y, Spengler ML, Kuropatwinski KK, Comas-Soberats M, Jackson M, Chernov MV, Gleiberman AS, Fedtsova N, Rustum YM, Gudkov AV, Antoch MP. Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1. Oncotarget. 2011 Dec;2(12):1279-90. PMID:22249125.
Spengler ML, Kuropatwinski KK, Comas M, Gasparian AV, Fedtsova N, Gleiberman AS, Gitlin II, Artemicheva NM, Deluca KA, Gudkov AV, Antoch MP. Core circadian protein CLOCK is a positive regulator of NF-kappaB-mediated transcription. Proc Natl Acad Sci U S A. 2012 Sep 11; 109 (37):E2457-65. doi: 10.1073/pnas.1206274109. Epub 2012 Aug 15.