Dr. Amaral pursued full-time University teaching and research careers being the latter fully dedicated to the basic and translational research of the genetic disease Cystic Fibrosis (CF) for the past 23 yrs. Basic research has its major focus on the molecular and cellular mechanisms of biogenesis, traffic, and degradation of normal and mutant membrane protein CFTR (CF transmembrane Conductance Regulator), which when mutated causes CF.
The overall goal of her research is to understand the molecular and cellular mechanisms of CF and to translate this knowledge into the benefit of patients. She has authored 112 international papers 57. Meanwhile, she has been continuously teaching at the University of Lisboa (at the Chemistry and Biochemistry Department) mostly Molecular Biology for 54 semesters with average teaching of ~9h per week.