Speaker Profile
Margaret E. Rice

Margaret E. Rice PhD

Neuroscience, Research and Clinical Research

New York, New York, United States of America

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Dr. Rice is a Professor in the Department of Neurosurgery and Department of Neuroscience and Physiology at New York University School of Medicine. Her NIH-funded laboratory studies factors that regulate the release of dopamine, a key transmitter in reward and motor pathways in the brain. Current research topics include modulation of axonal dopamine release in the striatum by diet and insulin, and the mechanism of somatodendritic dopamine release from neurons of the substantia nigra and ventral tegmental area. Dr. Rice is the current President of the International Society for Monitoring Molecules in Neuroscience (2014-2016) and a member of the Scientific Advisory Board of the Parkinson’s Disease Foundation.

Research in Dr. Rice's laboratory is focused on regulation of dopamine, a key transmitter in motor and reward pathways in the brain. The Rice group uses carbon-fiber microelectrodes with fast-scan cyclic voltammetry to provide real-time monitoring of axonal dopamine release in dorsal and ventral striatum and somatodendritic release in the substantia nigra and ventral tegmental area, primarily in brain slices. Complementary techniques include whole-cell recording of basal ganglia neurons, fluorescence imaging of calcium and reactive oxygen species (ROS), and immunocytochemistry. Current research is centered on a novel finding from the Rice group that hydrogen peroxide (H2O2), produced by mitochondrial respiration, is an endogenous regulator of synaptic and somatodendritic dopamine release, as well as dopamine neuron activity in the substantia nigra. Both dopamine release and dopamine neuron activity are suppressed by H2O2 via the activation of ATP-sensitive potassium (KATP) channels. Importantly, modulation by H2O2 is greater in the nigrostriatal dopamine pathway, which degenerates in Parkinson's disease (PD), than in the mesolimbic dopamine reward pathway that is relatively spared in PD. Given that mitochondrial dysfunction and oxidative damage have been linked causally to PD, these findings suggest that modulation by H2O2 is a double-edged sword. This diffusible messenger can rapidly link metabolism to neuron excitability; however, if generation or metabolism of H2O2 were disrupted, this could lead to oxidative damage. On-going studies are examining how H2O2 activates KATP channels, the time course of dopamine release regulation by H2O2, and how other neurons in the basal ganglia are affected by endogenous H2O2. In addition to these core project, the Rice group also studies regulation of axonal dopamine release by glutamate, GABA, calcium, cannabinoids and caffeine, the mechanism and regulation of somatodendritic dopamine release, and dopamine dysfunction in transgenic mouse models of dystonia and PD.
EVENTS & ACTIVITIES (Speaking, Spoken, and Authored)
  • In-Person Event In-Person Event
  • Speciality Psychiatry ...
  • Calendar Jun 25 - 29, 2016
  • Location New Orleans, Louisiana, USA