Malcolm K. BrennerMD, PhD
Dr. Malcolm Brenner is a member of the Center for Cell and Gene Therapy (CAGT) at Baylor College of Medicine, Texas Children’s Hospital, and Houston Methodist, which is responsible for the stem cell transplant programs at these institutions. Dr. Malcolm Brenner’s clinical interests span many aspects of stem cell transplantation, using genetic manipulation of cultured cells to obtain therapeutic effects. Dr. Malcolm Brenner’s laboratory research focuses on manipulating the anti-leukemic effector function to kill residual cancer cells after stem cell transplantation.
Efforts in Dr. Malcolm Brenner’s laboratory to analyze the cell of origin when relapse occurs in patients with acute myelogenous leukemia led Dr. Malcolm Brenner’s team to be the first to label autologous bone marrow cells genetically after purging, prior to their being reintroduced to the patient. Dr. Malcolm Brenner is studying the effects of gene transfer into autologous neuroblastoma cells and the use of gene-modified EBV-specific cytotoxic T lymphocyctes for prevention and treatment of lymphoproliferative disorders, Hodgkin’s disease, lung cancer and neuroblastoma.