M. Paola Castaldi PhD

Paola Castaldi is the global Head of Chemical Biology at AstraZeneca. Her team is focused on supporting drug discovery programs across all therapeutics areas using state of the art technologies with specific emphasis on target identification and validation, target engagement, and off-target determination. Since 2015, Paola has played a critical role to establish a therapeutic protein degradation platform at AstraZeneca providing both strategic and logistics directions. Before AstraZeneca, Paola was a key contributor of the Chemical Genetics group at Sanofi Oncology, Cambridge, MA with a focus on phenotypic drug discovery projects for the Wnt and KRAS oncogenic pathways.