Lior Zangi PhD

Lior Zangi, Ph.D., is an Associate Professor with Tenure at the Icahn School of Medicine at Mount Sinai, New York. He completed his education and training at the Weizmann Institute of Science, and Harvard University. Studies methods for delivering modified mRNA (modRNA) to the heart to induce cardiac regeneration, protection, or cardiovascular regeneration post-ischemic injury.

He has established a new method, modRNA-based, for minimal invasive gene delivery into specific cell types and organs. His early work showed the first successful delivery of modRNA into cardiac and skeletal muscle and pioneered using modRNA to treat ischemic disease. His invention led to the first successful Phase 2 cardiac modRNA therapeutic clinical trial using VEGFA modRNA. In the last few years, these modRNA technologies have been used for COVID-19 vaccinations and promoting cardiovascular regeneration in ischemic heart disease. Currently, Prof. Zangi’s laboratory investigates mRNA delivery methods into healthy or unhealthy specific cell types and organs, to fight different diseases such as heart failure and cancer.