Speaker Profile
Liangzhi Xie

Liangzhi Xie PhD

Pharmacy and Medicine
Beijing, Peking, China

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Dr. Xie obtained his doctor degree from the Biotechnology Process Engineering Center at Massachusetts Institute of Technology under the supervision of Prof. Daniel I.C. Wang. At MIT, Dr. Xie developed a stoichiometric model to optimize the design of mammalian cell culture medium and the control of the dynamic culture environment. In 1994, he was able to achieve a record cell density of 1.7 x 107 cells/ml and a record antibody titer of 2.4 gram/L. He then worked on viral vaccine process development and cGMP manufacturing for three US FDA approved products (Varicella® , Zostervax® , and ProQuad® ) at Merck Research Laboratory, Merck & Company. He also led the cell culture and viral vaccine process development and cGMP clinical production for Merck’s adenovirus based HIV vaccine and helped to develop by far the largest scale (2000L) of human viral vaccine process under serum-free condition in stirred-tank bioreactors. He is also the director and professor at the Cell Culture R&D center at the Peking Union Medical College since 2002.
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