Leif Daniel NelinChief, Professor | Columbus, Ohio
Dr. Nelin is the Division Chief of Neonatology at Nationwide Children’s Hospital and a Professor of Pediatrics at The Ohio State University College of Medicine. Clinically, Dr. Nelin is particularly interested in respiratory diseases, specifically in how pulmonary blood flow affects newborn respiratory diseases. Thus, persistent pulmonary hypertension of the newborn(PPHN) is one of his primary clinical interests. This has lead to his research interest in nitric oxide (NO), a potent vasodilator whose production is decreased in patients with PPHN. Utilizing cell culture techniques, isolated perfused lungs and animal preparations.
Dr. Nelin studies the mechanisms that determine biological availability of the amino acid L-arginine on the ability of the lungs to produce NO and thereby regulate blood flow. The ultimate goal of this research is to understand the pathophysiology of PPHN and to develop new and specific therapies for the treatment of lung diseases that are characterized by alterations in NO production. A second area of research interest is the study of the developmental toxicology of inhaled NO.