Keisuke Ito MD, PhD

Keisuke Ito's central research goal of Lab is to expand understanding of the regulatory pathways controlling the equilibrium of stem cells, with a special focus on developing novel therapeutics for hematopoietic disorders. At the core of his work is the process of stem cell division, and the resulting balance between self-renewal or differentiation, which directly impacts tissue homeostasis. We are also devoting increased attention to targeting cellular metabolism as a therapeutic strategy, and have cut a path along the leading edge of research into the role of epigenetic-microRNA crosstalk, including physiologically relevant Ten-eleven translocation, in the pathogenesis of the myelodysplastic syndrome. His expertise in stem cell biology, hematology, and the bone marrow microenvironment, combined with the development of single-cell approaches and live imaging to tracking stem cell fate in animal models, will together facilitate a major contribution to the improvement of transplantation efficiency and the development of new therapies and treatments, and potentially even cures, for many forms of hematologic pathology.