Karl-dimiter Bissig MD, PhD

Dr. Karl-Dimiter Bissig, associate professor of molecular and cellular biology, has focused his research on human liver disease and human disease modeling.

His three most recent works were published in Nature Communications. In his first paper, Bissig introduced the first xenograft model for metabolic liver disease. This mouse model more closely resembles human disease modeling, offering the ability to validate human experimental therapies. These new models are of particular relevance to macromolecular therapies, which are sequence or epitope specific, and cannot be validated in experimental animal models. This process supports the rapid translation of therapy from lab to clinical trials. His work was also featured in “research highlights” in Nature Reviews Endocrinology.