Jyoti Malhotra MD, MPH

Medical oncologist Jyoti Malhotra, M.D., M.P.H., centers her philosophy of care on learning as much as possible about each patient—what is important to them, the challenges they face, and the therapeutic approach they want to take—as well as the details of their disease. She aims to free them up to focus on healing while she and her colleagues take care of things such as navigating the system and keeping the care plan moving in the right direction.

In her capacity as director of thoracic medical oncology at the Lennar Foundation Cancer Center at the City of Hope Orange County, she is excited about offering patients an expansive slate of early-phase clinical trials to offer more people access to new therapies. Dr. Malhotra’s expertise is in Experimental Therapeutics and she has led multiple phases I trial investigating novel agents and combinations for cancer therapy including first-in-human trials. She aims to bring together advances in precision medicine, which targets treatment to the molecular and genetic characteristics of each tumor, and immunotherapy, which harnesses the body’s natural defenses to fight cancer. Dr. Malhotra leads multiple investigator-initiated clinical trials as well as a national trial sponsored by the National Cancer Institute- Cancer Therapy Evaluation Program (CTEP). She has authored more than 100 publications, book chapters, and abstracts.

Dr. Malhotra earned her medical degree from Maulana Azad Medical College at the University of Delhi in India, and then a master’s from the Bloomberg School of Public Health at Johns Hopkins University. She was an internal medicine resident at Georgetown University/Washington Hospital Center and an oncology/hematology fellow at Mount Sinai Medical Center in New York. Her previous appointments were at Memorial Sloan Kettering Cancer Center, Mount Sinai, and, most recently, Rutgers Cancer Institute of New Jersey, where she was a leader of Phase I/Investigational Therapeutics program.