Jon C. Aster MD, PhD

Dr. Jon Aster is the Michael Gimbrone Professor of Pathology at Brigham and Women’s Hospital and Harvard Medical School and Director of Hematopathology at Brigham and Women’s Hospital. Jon obtained his MD/Ph.D. in 1987 from the University of Michigan and then did clinical training in Anatomic Pathology and Hematopathology at Brigham and Women’s Hospital. His postdoctoral work was conducted in the laboratory of Dr. Jeffrey Sklar at BWH.

Research in the Aster lab focuses on the role of Notch signaling in cancer and hematopoiesis. His lab has led or collaborated on work that has produced a number of firsts in the field, including the production of the first mouse model of Notch-induced leukemia and detection and characterization of frequent Notch mutations in human T-cell acute lymphoblastic leukemia, an observation that leads to ongoing attempts to target Notch in cancers.