John (jay) Schneekloth PhD

Dr. Schneekloth received his undergraduate degree from Dartmouth College in 2001, where he worked with Prof. Gordon Gribble. He then moved to Yale University and obtained a Ph.D. from the chemistry department with Prof. Craig Crews in 2006. As a graduate student, he studied natural product total synthesis and chemical biology relating to the ubiquitin-proteasome pathway.

He then pursued an NIH postdoctoral fellowship with Prof. Erik Sorensen at Princeton University, where he worked on the development of a new multicomponent reaction and the application of this reaction to the synthesis of analgesic natural products. He returned to Yale in 2009 where he worked as a medicinal chemist at the Yale Small Molecule Discovery Center.

In 2011, Dr. Schneekloth joined NCI where his research involves using synthetic chemistry and high throughput chemical biology approaches to develop chemical probes of signal transduction pathways and gene expression. Specific areas of interest include protein sumoylation (including mechanistic probes, natural products, and synthetic inhibitors) and the use of small molecule microarrays to identify RNA- and DNA-binding small molecules.