John C. Yoon MD, PhD

Dr. Yoon is interested in molecular studies of metabolic regulation and human disease, with a particular focus on diabetes mellitus. Ongoing work utilizes a combination of experimental systems and approaches to investigate the role of specific intracellular signaling pathways such as the Wnt pathway in the regulation of muscle metabolism and their impact on physiological and pathological adaptations.
Another area of interest is the contribution of mitochondrial defects and inflammatory processes to the development of metabolic disease. Large-scale genetic screens in muscle cells have been performed to isolate regulators of mitochondrial function and some of the identified genes are being characterized.