James (jim) Huntington PhD

Dr. Jim Huntington, Professor of Molecular Haemostasis at the University of Cambridge, is internationally recognized for elucidating the basic structural mechanisms of proteins that control blood coagulation and for applying this knowledge to develop potential therapeutics. His group has solved crystal structures of serpin polymers, revealing the mechanism of misfolding that can lead to thrombosis, emphysema, cirrhosis, and dementia, and suggesting how ‘chemical chaperones’ might rescue folding. Professor Huntington’s group has also made significant discoveries on proteins and protein complexes that regulate the formation of blood clots, including prothrombinase and thrombin.