Jessica Tyrrel MD

Jess is a Diabetes Research and Wellness Foundation Research Fellow. Her research aims to use genetics to understand the factors contributing to the risk of developing type 2 diabetes.The majority of her research utilises the UK Biobank data set. re are several strands to her work in this area. This dataset has over 500,000 people and as such is a very powerful epidemiological resource. The Biobank is genotyping all participants and Dr Tyrrell will be utilisng this data to understand what factors may have a causal relationship in type 2 diabetes. She has also created liability scores for type 2 diabetics using classical risk factors and is currently investigating both environmental and genetic factors which may drive an individual’s presence in phenotypic extremes.

Her publications are as follows:
Tyrrell JS, Taylor MS, Whinney D, Osborne NJ (2015). Associations of Leg Length, Trunk Length, and Total Adult Height with Ménière's: Cross-Sectional Analysis in the UK Biobank. Ear Hear, 36(3), e122-e128. Abstract.
Tyrrell J, White M, Barrett G, Ronan N, Phoenix C, Whinney D, Osborne N (2015). Mental Health and Subjective Wellbeing of individuals with Ménière's: Cross Sectional Analysis in the UK Biobank. Otology & Neurotology.
Kendall M, Hodges NJ, Whitwell H, Tyrrell J, Cangul H (2015). Nanoparticle growth and surface chemistry changes in cell-conditioned culture medium. Philos Trans R Soc Lond B Biol Sci, 370(1661). Abstract.
Sharpe RA, Thornton CR, Tyrell J, Tyrrell J, Nikolaou V, Osborne NJ (2015). Variable risk of atopic disease due to indoor fungal exposure in NHANES 2005-2006. Clinical and Experimental Allergy.
Freathy RM, Tyrrell J, Bradfield JP, Cavadino A, Feenstra B, Hayes MG, Hottenga JJ, Huikari V, Kreiner-Moller E, Metrustry S, et al (2014). Genetic analyses identify positive causal effects of maternal fasting glucose, Type 2 diabetes and vitamin D levels, and an inverse causal effect of maternal blood pressure, on offspring birth weight. Diabetic Medicine, 31, 18-18.