Jason Mccoy PhD

Jason McCoy is a research scientist at MITRA, a research group directed by Scott Vafai at the Broad Institute of MIT and Harvard. MITRA is part of the Broad Metabolism Program, with a mission to discover novel mitochondrial therapeutics. The focus of McCoy’s work is on developing assays to identify small-molecule modulators of target proteins involved in mitochondrial disease.

Before joining the Broad Institute in 2015, McCoy obtained his Ph.D. at the University of Wisconsin, Madison, where he studied structure-function relationships in enzymes through X-ray crystallography and activity assays. As a postdoc, he worked with Crina Nimigean at Weill Cornell Medical College and Ming Zhou at Baylor College of Medicine. His research focused on studying ion permeation, selectivity, and ligand gating in channels, as well as conformational dynamics of membrane transporters using a variety of biophysical methods. These included X-ray crystallography, electrophysiology with planar lipid bilayers, stopped-flow liposomal assays, and ITC using channels reconstituted into nanodiscs.