Ingrid Flemin PhD

Ingrid Fleming (born in Northern Ireland) obtained her BSc (First Class, Combined Honours) in Biochemistry and Pharmacology at Aston University in England and her PhD at the Louis Pasteur University in Strasbourg, France. Prof. Fleming is currently Chair of the Institute for Vascular Signalling and her research focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium and on the generation of several “autacoids”; including nitric oxide (NO) and the so-called endothelium–derived hyperpolarizing factor (EDHF). Current projects are aimed at elucidating the role of cytochrome P450-derived lipid mediators in vascular homeostasis, angiogenesis and stem cell mobilisation, as well as the changes in platelet function associated with the development of type 2 diabetes. Ingrid Fleming is a member of the Excellence Cluster Cardio-Pulmonary Systems (ECCPS) steering committee and currently president of the European Vascular Biology Organisation.

Her publications are as follows:
Randriamboavonjy, V. et al.: AMPK {alpha}2 subunit is involved in platelet signaling, clot retraction, and thrombus stability. In: Blood 116, 2010. pp. 2134-2140.
Loot, A.E. et al.: Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase. In: J Exp Med 206, 2009. pp. 2889-2896
Randriamboavonjy, V. et al.: Platelet SERCA-2 and µ-calpain activity are altered in type 2 diabetes and restored by rosiglitazone. In: Circulation 117, 2008. pp. 52-60.
Fisslthaler, B. et al.: Inhibition of endothelial nitric oxide synthase activity by proline-rich tyrosine kinase 2 in response to fluid shear stress and insulin. In: Circ Res. 102, 2008. pp. 1520-1528.
Fisslthaler, B. et al.: Fluid shear stress and NO decrease the activity of the hydroxy-methylglutaryl coenzyme A reductase in endothelial cells via the AMP-activated protein kinase and FoxO1. In: Circ. Res. 100, 2007. e12-e21.
Fleming, I. et al.: Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells. In: Arterioscler Thromb Vasc Biol. 27, 2007. pp. 2612-2618.