Herve Broly PhD

Dr. Broly After a PhD in plant physiology in 1982, I worked at the Regional Blood Transfusion Centre of Lille (France) as Head of the Laboratory of Monoclonal Antibody from 1982 to 1991. I then took the position of Director Manufacturing and Development at Sorebio (Martillac, France), a Contract Manufacturing Organisation specialised in process development and manufacture of recombinant proteins expressed in mammalian cells. I became the general Manager of that company in 1997 after it was acquired by the Swiss biopharmaceutical company Serono. From 2003 to 2006, I took the position of Project Manager at Serono in Geneva, in charge of developing a New Biological Entity which entered Phase I in 2003. In 2006, I was appointed Vice-President Biotech Process Sciences at Serono in Vevey Switzerland. In that position, I’m responsible for the development and validation of drug substance manufacturing from cell line selection to market submission. These last years, we implemented the Quality by Design approach, we developed proprietary chemically-defined medium-based platform for the expression of recombinant proteins in CHO cells, and high throughput upstream, downstream and analytical methods to support strong process understanding. That work is now extended to the manufacture of drug substance in bacteria and yeast. More recently, we are focusing on developing tools for modulating the quality of recombinant proteins and on using new genetic tools for the detection and identification of adventitious agents in mammalian cell cultures.