Helmet T. Karim PhD

Dr. Helmet Karim is an assistant professor of psychiatry and bioengineering at the University of Pittsburgh. He is interested in the development of machine learning approaches for the treatment of mood disorders, as well as anxiety and dementia. In the ACE, he is working on the usage of an accelerated brain aging algorithm in the context of ASD.

Dr. Helmet Karim, Ph.D. was received a Ph.D. in Bioengineering at the University of Pittsburgh, focusing on the prediction of treatment response in late-life depression (LLD) with pharmacological functional magnetic resonance imaging (phFMRI) and machine learning approaches. We found that prediction of response was feasible using fMRI after only a single dose of medication and machine learning approaches that utilized kernels (e.g., principal components analysis). We found that the early neural changes (after a single dose and within a week of treatment) reflect later changes and differences in patients who eventually remit compared to those who do not remit.