Hans-willem Snoeck MD, PhD

Dr. Snoeck was trained as clinical hematologist, with a focus on bone marrow transplantation, and from that clinical interest developed a research program in hematopoietic stem cell biology, more specifically mechanisms regulating stem cell renewal and underlying quantitative genetic variation in the behavior of hematopoietic stem cells among inbred mouse strains.

Expansion of this program into directed differentiation of ES and iPS cells into thymic epithelial cells arose from the desire to attempt to alleviate post-bone marrow transplantation immune deficiency, caused, among others, by defective T cell reconstitution. In addition, through these studies into the development of anterior foregut endoderm from ES and iPS cells, the lab also focuses on the generation of lung tissue from pluripotent cells.