Gregory Dussor PhD, BS

Dr. Greg Dussor’s research focus is on uncovering pathological mechanisms and therapeutic targets for migraine headache. Since the most likely mechanism contributing to migraine pain is activation of peripheral nociceptive signaling from the meninges, experiments in the Dussor laboratory have focused on identifying cellular mechanisms of dural afferent activation/sensitization as well as understanding plasticity at the central terminals of these neurons. Published manuscripts resulting from this work have identified targets within the afferent nociceptive system that innervates the meninges, including acid-sensing ion channels, several TRP channels, and IL-6 signaling mechanisms. They have also identified non neuronal cells (fibroblasts) as potential contributors to afferent signaling from the meninges.