Gregory Cascino MD

Dr. Gregory D. Cascino is a nationally recognized neurologist, epileptologist, and professor of neurology at Mayo Clinic in Rochester, Minnesota. He serves as the Whitney MacMillan Jr. Professor of Neuroscience and Enterprise Chair of the Division of Epilepsy within the Department of Neurology. Throughout his distinguished career, he has been dedicated to improving the diagnosis, treatment, and long-term outcomes of patients with epilepsy and seizure disorders.

Dr. Cascino earned his Doctor of Medicine degree from Rush Medical College after completing undergraduate studies in biological sciences at Northwestern University. He completed residency training in internal medicine at Duke University Medical Center, followed by neurology residency training at Harvard Medical School and a clinical fellowship in neurology at Massachusetts General Hospital, Harvard University. He is board-certified in Internal Medicine, Neurology, and Epilepsy by the American Board of Psychiatry and Neurology.

His clinical expertise focuses on epilepsy, drug-resistant seizure disorders, and advanced epilepsy management. Dr. Cascino has been a leader in the development and application of sophisticated diagnostic techniques, including structural and functional neuroimaging, long-term electroencephalographic monitoring, intracranial EEG recordings, and epilepsy surgery evaluation. His work has helped advance treatment options for patients with medically refractory epilepsy, with the goal of achieving seizure freedom while minimizing treatment-related side effects and improving quality of life.

An accomplished researcher, Dr. Cascino has led and contributed to numerous clinical studies involving epilepsy surgery outcomes, epilepsy genetics, cannabinoid-based therapies, rescue seizure medications, and novel treatment approaches for focal epilepsy. He has also participated in major initiatives such as the Human Epilepsy Project and the Epilepsy Genetics Initiative, helping to advance personalized approaches to epilepsy care. His extensive body of scholarly work has significantly influenced modern epilepsy diagnosis and treatment strategies.

Dr. Cascino has held numerous leadership roles within major neurological and epilepsy organizations, including the American Academy of Neurology, American Epilepsy Society, American Neurological Association, and Epilepsy Foundation of America. His contributions to the field have been recognized with prestigious honors such as the President’s Award from the American Academy of Neurology, the J. Kiffin Penry Excellence in Epilepsy Care Award from the American Epilepsy Society, and the Champion in Epilepsy Care Award from the Epilepsy Foundation of Minnesota.