Giuseppe Caprio PhD

Dr. Giuseppe Di Caprio, Ph.D. is an Instructor in Pediatrics at Harvard Medical School. He completed his Doctor of Philosophy at the University of Naples Federico II. His research bridges Optical Microscopy, Biology, and Image Processing. He is interested in mechanistic questions addressed at a molecular level aided by fluorescence microscopy imaging acquired with high temporal and spatial resolution. During the past years, he focused on problems associated with viral particles endocytosis and fusion processes, in-vitro assembly of clathrin-coated pits, the shape of intracellular energy gradients in living cells, Pyrin-mediated inflammasome assembly and activation, and the mechanisms that regulate cell internalization of Transferrin-decorated DNA origami barrels. Aspects of his studies involve close collaborations with other members of the Kirchhausen group and with external collaborators. Most of the imaging is carried out using minimally invasive, 3D live-cell lattice light-sheet microscopy (LLSM); he has also been responsible for implementing the construction of one of these microscopes in the Kirchhausen lab as well as developing the computational processing tools used for the quantitative analysis of the data generated by me and by other members of our group.