Gerald S. Shadel MD

Dr. Gerald Shadel studies the basic biology of mitochondria and mtDNA, and, in doing so, has identified novel ways that mitochondria contribute to disease, aging, and the immunesystem. He is also interested in understanding how mitochondria are involved in cellular signaling processes. He seeks to identify what the signals are, what pathways they trigger, and how they play a part in aging, cancer and metabolic and degenerative diseases. His group takes a multidisciplinary view, exploring mitochondrial function—and dysfunction—via cultured cells, model organisms and other genetic and biochemical approaches.