Gabriella Campadelli-Fiume earned her Science Doctor (1968) and Specialization in Virology (1972) degrees at University of Bologna. Currently, Dr. Campadelli-Fiume is a Professor of Virology at the University of Bologna, Italy. She is a founding member of the Italian Society of Virology, European Society of Virology, European Academy of Microbiology, a member of Editorial Board of Journal of Virology and have a co-organized a number of international meetings.
Her work focuses on HSV entry into the cell, virus-induced cell fusion, and virus exit out of the cell. She discovered that HSV induces dramatic modifications to the exocytic pathway, Golgi apparatus and cytoskeleton, and later identified the modified multivesicularbodies as site of HSV assembly. She contributed to define the cell and viral factors required for HSV penetration of human cells. Years ago, she demonstrated that HSV gD serves as receptor-binding glycoprotein; independently discovered nectin1 as HSV receptor, and later found that gD serves also as the trigger of fusion, by forming complexes with gH/gL and gB. Recently, she identified avb3-integrin as a determinant in the HSV choice of the entry pathway. She developed a strategy to convert HSV into an oncolytic agent, by retargeting HSV tropism to selected receptors present in tumor cells, and demonstrated the oncolytic activity of the retargeted onco-HSV in mice.