Dr. Faye's laboratory integrates clinical work to define the biological and molecular effects of the modulation of signal transduction pathways in head and neck squamous cell carcinoma (HNSCC) and non-small cell lung cancer (NSCLC). She has identified novel mechanisms of sensitivity and resistance to kinase inhibitors including polo-like kinase 1 (PLK1), Src, STAT3, and phosphoinositide 3-kinase (PI3K) pathway inhibitors. She has demonstrated the ability to translate her laboratory work to the clinic with several clinical trials of c-Src inhibitors. Additionally, her laboratory was the first study to establish a therapeutic vulnerability of NOTCH1-mutant HNSCC to any class of drugs leading to the initiation of a clinical trial testing a PI3K/mammalian target of rapamycin (mTOR) inhibitor in NOTCH1-mutant HNSCC (NCT03740100). This ongoing research is funded by the NIH (R01) and CPRIT.
Recently, they have discovered that inhibition of Aurora kinase in HPV+ cancers leads to apoptosis and immunogenic cell death. These findings are the basis for her investigator-initiated clinical trial (NCT04555837) combining the inhibition of Aurora-A (alisertib) and PD1 (pembrolizumab). This ongoing research is funded by the NIH (R01).