Ernesto Guccione PhD

Ernesto Guccione is a Professor of Oncological Sciences at Icahn School of Medicine at Mount Sinai. During his Ph.D. at the International Center for Genetic Engineering Biotechnology (1CGEB), he studied the oncogenic functions of HPV E6/E7 viral proteins and the relevance of splicing in regulating E6 functions. In his postdoctoral work at the European Institute of Oncology, he studied the role of chromatin in defining c-MYC target site recognition. He has also identified PRMT6, a member of the Protein Arginine MethylTransferase (PRMT) family, as an important enzyme regulating transcriptional repression.

In 2008 he started his lab at A*STAR in Singapore where he was promoted to Research Director and Coordinated the program of Epigenetics and Diseases. My lab has a long-standing interest in understanding the basic mechanisms of transcriptional and post-transcriptional regulation in order to identify therapeutic opportunities in oncology.