Matt Hoffman DO, PhD

Matt Hoffman, DO, PhD, is a neurologist, clinical neurophysiologist, and physician-scientist at Mayo Clinic in Rochester, Minnesota. He specializes in neuromuscular disorders, electromyography (EMG), evoked potential testing, and intraoperative neurophysiological monitoring. His clinical expertise encompasses conditions such as amyotrophic lateral sclerosis (ALS), primary lateral sclerosis, myasthenia gravis, peripheral nerve disorders, and other diseases affecting the peripheral nervous system.

Dr. Hoffman earned both his Doctor of Osteopathic Medicine and PhD degrees, establishing a strong foundation in clinical neuroscience and translational research. His career has combined patient care with scientific investigation, allowing him to bridge fundamental neuroscience discoveries with practical applications in neurology and neurophysiology. Through advanced training in neurology and clinical neurophysiology, he developed specialized expertise in diagnostic testing and neurological monitoring techniques that are essential for the management of complex neuromuscular disorders.

His clinical interests include electromyography, evoked potentials, neuromuscular diseases, intraoperative neurophysiological monitoring, and disorders of nerve and muscle function. He is particularly recognized for his work in applying neurophysiological techniques to improve diagnostic accuracy, surgical safety, and neurological outcomes for patients undergoing complex procedures.

As a researcher, Dr. Hoffman has authored numerous peer-reviewed publications spanning neuromuscular medicine, neurophysiology, peripheral neuropathy, multiple sclerosis, intraoperative monitoring, spinal cord injury prevention, and neurosurgical monitoring technologies. His investigations have explored topics including small fiber neuropathy, myopathies, neuromuscular complications of systemic disease, electromyographic monitoring techniques, and innovative applications of neurophysiology in surgical and critical care settings.