Donald G.stein PhD

Stein's early findings on sex differences in recovery from brain injury led to decades of research on neurosteroids in CNS injury. His laboratory now studies the actions of progesterone and its metabolites in pediatric, adult and aged models of TBI and stroke. Using cell culture, molecular biological and immunocytochemical techniques, his group works with medical colleagues in emergency medicine, neurology, radiology, pediatrics and neuro-ophthalmology to examine how different kinds of brain injuries can be repaired at the morphological and functional levels.
His research has served as the basis for two independent Phase II clinical trials testing progesterone for moderate to severe traumatic brain injury, now completed, and an NIH-sponsored, nationwide Phase III clinical trial now underway. Current lines of research in his lab include the investigation of combinatorial pharmacotherapies, and a focus on the pleiotropic actions of neurosteroids and the systemic nature of CNS injury. Dr. Stein is the author of hundreds of articles, book chapters, reviews and papers on the subject of recovery from brain injury