David Mangelsdorf PhD

Dr. David J. Mangelsdorf received his BS in Biology and Chemistry from Northern Arizona University in Flagstaff (1981) and his PhD in Biochemistry from the University of Arizona in Tucson (1987). He did his postdoctoral studies at The Salk Institute for Biological Studies. Since 1993 he has been at UT Southwestern, where he currently is Professor and Chair of the Department of Pharmacology, and an Investigator of the Howard Hughes Medical Institute. He holds the Raymond and Ellen Willie Distinguished Chair in Molecular Neuropharmacology, in Honor of Harold B. Crasilneck, PhD and the Distinguished Chair in Pharmacology, and he is a member of the National Academy of Sciences.

His publications are as follows:
FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ Science 2011 Mar 331 6024 1621-4.
Endocrine Regulation of the Fasting Response by PPARalpha-mediated Induction of Fibroblast Growth Factor 21 Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., Elmquist, J.K., Gerard, R.D., Burgess, S.C., Hammer, R.E., Mangelsdorf, D.J., Kliewer, S.A. Cell Metabolism 2007 5 415-425.
Identification of a nuclear receptor for bile acids. Makishima, M., Okamoto, A.Y., Repa, J.J., Tu, H., Learned, R.M., Luk, A., Hull, M.V., Lustig, K.D., Mangelsdorf, D.J., and Shan, B. Science 1999 284 362-365.
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor, LXR?. Peet, D.J., Turley, S.D., Ma, W., Janowski, B.A., Lobaccaro, J.A., Hammer, R.E., and Mangelsdorf, D.J. Cell May 1998 93 693-704.
Identification of an oxysterol signaling pathway mediated by the nuclear receptor, LXR-alpha Janowski, B.A., Willy, P.J., Rama Devi, T., Falck, J.R., and Mangelsdorf, D.J. Nature 1996 383 728-731.