David M. Markusic PhD

David M. Markusic, Ph.D. has over ten years of research experience optimizing liver gene delivery in murine and canine disease models using different viral vector systems. He has successfully obtained competitive funding from the NIH, Bayer Hemophilia Awards Program, and Pfizer Aspire Hemophilia Awards to work on optimizing adeno-associated virus liver gene delivery in murine and canine hemophilia B animal disease models, to elucidate the mechanism of tolerance induction with pre-existing immunity, to model and minimize detrimental anti-vector immune responses, to define minimally effective vector doses, and to assess the risks of administering suboptimal vector doses.