David J. Loane PhD

David Loane, PhD, is an Assistant Professor of Anesthesiology and Faculty Member at the Center for Shock, Trauma and Anesthesiology Research (STAR) at the University of Maryland School of Medicine, Baltimore, Maryland. Dr. Loane conducted his graduate studies at the Department of Pharmacology and MRC Center for Synaptic Plasticity, University of Bristol, England, and obtained his PhD in Neuroscience in 2005. He then pursued postdoctoral training with Dr. Marina Lynch at Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland, where he studied neuroinflammatory changes in the aged and Alzheimer's disease (AD) brain. In 2007 Dr. Loane was recruited to the Department of Neuroscience, Georgetown University Medical Center, Washington D.C., to perform further postdoctoral training on experimental models of traumatic brain injury (TBI) under the mentorship of Dr. Alan Faden. He joined the faculty of the University of Maryland School of Medicine in November 2009 and is currently Assistant Professor of Anesthesiology.

His Publications are as follows:
Kabadi SV, Stoica BA, Loane DJ, Luo T, Faden AI. Cell cycle inhibition limits microglial activation, astrocytosis, neuronal loss and neurological dysfunction after experimental traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism. 34 502-13, 2014.
Stoica BA, Loane DJ, Zhao Z, Kabadi SV, Hanscom M, Byrnes KR, Faden AI. PARP-1 inhibition attenuates neuronal loss, microglia activation and neurological deficits after traumatic brain injury. Journal of Neurotrauma. 31 758-772, 2014.
Sabirzhanov B, Zhao Z, Stoica BA, Loane DJ, Wu J, Borroto C, Dorsey S, Faden AI. Down-regulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of pro-apoptotic Bcl-2 proteins. Journal of Neuroscience. 34 10055-71, 2014.
Loane DJ, Stoica BA, Tchantchou F, Kumar A, Barrett JP, Akintola T, Xue F, Conn PJ, Faden AI. Novel mGluR5 positive allosteric modulator improves functional recovery, attenuates neurodegeneration, and alters microglial polarization after experimental TBI. Neurotherapeutics. 11 857-69, 2014.