David Gutman MD, PhD

Dr. Gutman received his Ph.D. in Neuroscience in 2005 and MD from Emory University in 2005. Following completion of medical school he completed a residency in Psychiatry in 2009. Following residency, he has worked as a research scientist in the Center for Comprehensive Informatics (CCI), and is now an assistant professor of biomedical informatics. Broadly, Dr. Gutman is interested in using digital imaging technologies to answer important questions in neurosciences. Specifically, his work focuses on mining digital pathology and radiology imaging from glioma patients and correlating imaging based features with genetic and clinical variables. In addition, he maintains a strong interest in using DTI and MRI based techniques to understand neural circuitry.

His Ph.D. work focuses on investigating the behavioral effects of novel corticotrophin releasing factor receptor antagonists in animal models of depression and anxiety. Specifically he investigated the compound R121919, a CRF1 receptor selective antagonist. CRF modules the behavioral and endocrine effects of acute and chronic stress, and his work focused on how acute and chronic treatment with R121919 affected behavioral responses to novel stressors, as well as the biochemical/neuroendocrine effects of long-term CRF receptor antagonist treatment. One of the focuses of this work was to use in situ hybridization to measure alterations in receptor expression throughout the brain following treatment, as well as measure alterations in HPA axis function.