David D. Moore AB, PhD

Prof. David D. Moore is a professor of Cell Biology at Baylor College of Medicine. Prof. Moore’s primary research interest is in functions of members of the nuclear hormone receptor superfamily. As a world leading scientist, Dr. Moore is working to understand the roles of the newer members of this superfamily, particularly their impact on metabolic and oncogenic pathways in the liver. Recently, his lab found that both FXR and PPARα regulate hepatic autophagy and FXR regulates a number of key metabolic target genes including SHP, an unusual orphan receptor. Dr. Moore will discuss his new findings about the mechanism of action of nuclear receptors FXR and PPARα in liver energy balance.