Daniel M. Margolis MD

David Margolis is the Director of the University of North Carolina at Chapel Hill HIV Cure Center, funded in part by a public-private partnership between UNC and GlaxoSmithKline, and is the principal investigator for the NIH-sponsored Collaboratory of AIDS Researchers for Eradication. He has an MD from Tufts and trained in medicine and infectious diseases at the New England Medical Center, and the NIAID. He and many collaborators have begun to develop drug and immunotherapy approaches to target persistent HIV, the tools needed to cure HIV infection.

He has treated people with HIV infection and studied the molecular interactions between HIV and the host since the pandemic emerged during his medical training. His laboratory studies interactions between HIV and the host cell on the molecular level, with an eye to using these insights to improve the treatment of HIV infection, and the management of the HIV pandemic. Current work focuses on the molecular mechanisms that control the latent reservoir of HIV infection within resting T cells. The group has described selected members of the family of chromatin-modifying enzymes, histone deacetylases, which act at the proviral promoter to enforce latency. The laboratory is attempting to test novel reagents that perturb latency in T cells obtained from HIV+ patients, followed by clinical experiments that attempt to deplete persistent HIV infection and develop the tools needed to cure HIV infection.